When Metabolism Became Messaging
The Stepwise Evolution of the GABAergic Signaling System
Thakur A, Kulharia M.
Read the bioRxiv preprint ↗Evolutionary biology
How did chemical signals
become biological communication?
Neurotransmitter phylogenies and models of signalling-system evolution.
Our research examines the evolutionary histories of the molecular components involved in neurotransmitter synthesis, metabolism, transport and reception. Comparative sequence analysis and phylogenies provide a basis for developing and testing models of how these systems were assembled and diversified.
This programme connects the study of present-day molecular function with a deeper question: how did existing biological components acquire new roles in communication? It forms part of our broader effort to understand why life is the way it is.
Selected bioRxiv preprints
Preprints are research manuscripts shared before peer review.
From Metabolite to Signalling
Evolutionary Assembly of the Glutamatergic System Across Metazoans
Kulharia M, Thakur A.
Read the bioRxiv preprint ↗Evolutionary Diversification of Nitric Oxide Signaling Components Across Metazoa
A Comparative Phylogenomic Analysis
Thakur A, Kulharia M.
Read the bioRxiv preprint ↗